Drug Interactions With Fluticasone and Salmeterol

Drug interactions with fluticasone and salmeterol may occur with a variety of medications. Among the drugs that can potentially interact with fluticasone and salmeterol are beta blockers, certain antibiotics, and some diuretics. Several potential drug interactions with fluticasone and salmeterol can increase your risk of side effects, such as low potassium levels, an irregular heart rhythm, or dangerously low blood pressure. Some of these interactions may also decrease the effectiveness of the medications.

 

An Overview of Drug Interactions With Fluticasone and Salmeterol

Fluticasone and salmeterol (Advair®) can potentially interact with a number of other medicines. Some of these medicines that may lead to fluticasone and salmeterol interactions include:
 
  • Beta blockers, such as:

 

 

  • Certain antibiotics or antifungals, including:

 

    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)

 

  • Certain diuretics, such as:

 

 

  • Digoxin (Digitek®, Lanoxin®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

 

 

 

 

(Drug Interactions With Fluticasone and Salmeterol Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;