COPD Home > Combivent Drug Interactions

Combivent drug interactions may occur if it is taken with certain medications, such as digoxin, tricyclic antidepressants, and certain diuretics. These interactions can increase your risk of side effects, decrease the medications' effectiveness, or cause dangerously low blood pressure. Therefore, you should consult your healthcare provider to discuss potential Combivent drug interactions that may apply to you.

An Overview of Combivent Drug Interactions

In order to comply with the Montreal Protocol on Substances That Deplete the Ozone Layer, Combivent inhalers (in their original form) will not be available after July 2013 because they contain chlorofluorocarbons (CFCs), chemicals that deplete the ozone layer. A new formulation, Combivent Respimat, became available starting in October 2012. People using the old Combivent inhaler will need to get a new prescription in order to switch to the new Combivent Respimat inhaler.


Combivent® (ipratropium and albuterol inhaler) can potentially interact with a few other medicines. Some of the medicines that may lead to Combivent drug interactions include:
  • Acetylcholinesterase inhibitors, such as:
  • Anticholinergic medications, such as:
  • Certain diuretics, such as:
  • Digoxin (Digitek®, Lanoxin®)
  • Monoamine oxidase inhibitors (MAOIs), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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