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Spiriva Drug Interactions
If certain medications are combined with Spiriva, drug interactions may occur. These interactions can increase your risk of side effects or decrease the medications' effectiveness. If Spiriva drug interactions are a concern, your healthcare provider may monitor you more closely or adjust your dose. Drug interactions are especially a concern if you are taking anticholinergic medications or acetylcholinesterase inhibitors as well as Spiriva.
Spiriva® (tiotropium bromide) can potentially interact with a few other medicines. Some of the medications that may lead to Spiriva drug interactions include:
- Acetylcholinesterase inhibitors, such as:
- Donepezil (Aricept®)
- Galantamine (Razadyne™)
- Rivastigmine (Exelon®)
- Tacrine (Cognex®)
- Anticholinergic medications, including:
- Atropine
- Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
- Benztropine (Cogentin®)
- Clidinium (Librax®)
- Clozapine (Clozaril®)
- Darifenacin (Enablex®)
- Dicyclomine (Bentyl®)
- Diphenhydramine (Benadryl®, Tylenol PM®)
- Glycopyrrolate (Robinul®)
- Haloperidol (Haldol®)
- Homatropine (Hycodan®)
- Hyoscyamine (Levsin®)
- Ipratropium (Atrovent®)
- Scopolamine (Transderm Scop®)
- Tolterodine (Detrol®)
- Trospium (Sanctura®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD