Theophylline Drug Interactions (Cont.)

 
Cimetidine (Tagamet)
Taking theophylline with cimetidine can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Do not take cimetidine (even over-the-counter cimetidine) with theophylline without first talking with your healthcare provider.
 
Disulfiram (Antabuse)
Taking theophylline with disulfiram can increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
 
Estrogen
Taking theophylline with estrogen-containing products can increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
 
Fluvoxamine (Luvox)
Taking theophylline with fluvoxamine can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Do not take fluvoxamine with theophylline without first talking with your healthcare provider.
 
Interferon Alpha-2a (Roferon A) or Peginterferon Alpha-2a (Pegasys)
Taking theophylline with certain interferon medications can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Do not take an interferon medication with theophylline without first talking with your healthcare provider.
(Theophylline Drug Interactions Continued: Page 4)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;