Drug Combinations With Theophylline to Avoid

Lithium (Eskalith, Lithobid)
Theophylline can decrease the level of lithium in your blood, perhaps decreasing its effectiveness. If you are taking these drugs together, your healthcare provider may need to monitor the level of lithium in your blood and adjust your lithium dosage as necessary.
 
Methotrexate (Rheumatrex)
Taking theophylline with methotrexate can increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
 
Mexiletine (Mexitil)
Taking theophylline with mexiletine can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Do not take mexiletine with theophylline without first talking with your healthcare provider.
 
Moricizine (Ethmozine)
Taking theophylline with moricizine can decrease the level of theophylline in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage.
 
Pentoxifylline (Trental)
Taking theophylline with pentoxifylline can increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
 
Propafenone (Rythmol)
Taking theophylline with propafenone can increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
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