Theophylline Drug Interactions (Cont.)

 
Propranolol (Inderal, Inderal LA, InnoPran XL)
Taking theophylline with propranolol can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Do not take propranolol with theophylline without first talking with your healthcare provider.
 
Rifampin (Rifadin)
Taking theophylline with rifampin can decrease the level of theophylline in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage.
 
St. John's Wort
Taking theophylline with St. John's wort can decrease the level of theophylline in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage. During treatment with theophylline, do not start or stop taking St. John's wort without first talking with your healthcare provider.
 
Tacrine (Cognex)
Taking theophylline with tacrine can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Do not take tacrine with theophylline without first talking with your healthcare provider.
 
Ticlopidine (Ticlid)
Taking theophylline with ticlopidine can increase the level of theophylline in your blood, which can cause dangerous side effects. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary.
(Theophylline Drug Interactions Continued: Page 6)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;